9 research outputs found
I4U Submission to NIST SRE 2018: Leveraging from a Decade of Shared Experiences
The I4U consortium was established to facilitate a joint entry to NIST
speaker recognition evaluations (SRE). The latest edition of such joint
submission was in SRE 2018, in which the I4U submission was among the
best-performing systems. SRE'18 also marks the 10-year anniversary of I4U
consortium into NIST SRE series of evaluation. The primary objective of the
current paper is to summarize the results and lessons learned based on the
twelve sub-systems and their fusion submitted to SRE'18. It is also our
intention to present a shared view on the advancements, progresses, and major
paradigm shifts that we have witnessed as an SRE participant in the past decade
from SRE'08 to SRE'18. In this regard, we have seen, among others, a paradigm
shift from supervector representation to deep speaker embedding, and a switch
of research challenge from channel compensation to domain adaptation.Comment: 5 page
Heme oxygenase-1 repeat polymorphism in septic acute kidney injury
Abstract
Acute kidney injury (AKI) is a syndrome that frequently affects the critically ill. Recently, an increased number of dinucleotide repeats in the HMOX1 gene were reported to associate with development of AKI in cardiac surgery. We aimed to test the replicability of this finding in a Finnish cohort of critically ill septic patients. This multicenter study was part of the national FINNAKI study. We genotyped 300 patients with severe AKI (KDIGO 2 or 3) and 353 controls without AKI (KDIGO 0) for the guanine–thymine (GTn) repeat in the promoter region of the HMOX1 gene. The allele calling was based on the number of repeats, the cut off being 27 repeats in the S–L (short to long) classification, and 27 and 34 repeats for the S–M–L₂ (short to medium to very long) classification. The plasma concentrations of heme oxygenase-1 (HO-1) enzyme were measured on admission. The allele distribution in our patients was similar to that published previously, with peaks at 23 and 30 repeats. The S-allele increases AKI risk. An adjusted OR was 1.30 for each S-allele in an additive genetic model (95% CI 1.01–1.66; p = 0.041). Alleles with a repeat number greater than 34 were significantly associated with lower HO-1 concentration (p<0.001). In septic patients, we report an association between a short repeat in HMOX1 and AKI risk